Plexus suggests that Ease be taken at bedtime (on an empty stomach), and Nerve be taken in the morning. Click on the link below to see the full schedule.

Because Ease focuses on reducing inflammation, many take a "loading dose," to reduce inflammation as much as possible at the beginning. Depending on what your pain level is, that loading dose could be 2 to 6 capsules, 2 to 3 times a day.